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The role of clofarabine in acute myeloid leukemia

✍ Scribed by Ghanem, Hady; Kantarjian, Hagop; Ohanian, Maro; Jabbour, Elias

Book ID
115469749
Publisher
Informa plc
Year
2012
Tongue
English
Weight
671 KB
Volume
54
Category
Article
ISSN
1042-8194

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## Abstract Clofarabine is a second generation nucleoside analogue. It inhibits DNA repair and activates the mitochondrial apoptotic pathway leading to cell death. __In vitro__ clofarabine has demonstrated synergy with daunorubicin and Ara‐C and in phase II clinical trials has shown promising activ