The role of cell cycle in retinal development: Cyclin-dependent kinase inhibitors co-ordinate cell-cycle inhibition, cell-fate determination and differentiation in the developing retina

The cyclin-dependent kinase inhibitor ro

The cyclin-dependent kinase inhibitor roscovitine inhibits kinase activity, cell proliferation, multicellular development, and Cdk5 nuclear translocation in Dictyostelium discoideum

✍ Robert J. Huber; Danton H. O'Day 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 357 KB

## Abstract Roscovitine, a cyclin‐dependent kinase (Cdk) inhibitor, inhibited kinase activity and the axenic growth of __Dictyostelium discoideum__ at micromolar concentrations. Growth was almost fully rescued in 50 µM and ∼50% rescued in 100 µM roscovitine‐treated cultures by the over‐expression o