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The Role of Catechol-O-Methyltransferase in the Inactivation of Catecholestrogen

✍ Scribed by C. R. Creveling

Book ID
110439962
Publisher
Springer
Year
2003
Tongue
English
Weight
37 KB
Volume
23
Category
Article
ISSN
0272-4340

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## Abstract Prolonged exposure to unopposed estrogens is a major risk factor for the development of endometrial cancer. Oxidative metabolism of estradiol (E~2~) into the catecholestrogens (CEs), 4‐hydroxyestradiol (4‐OHE~2~) and 2‐hydroxyestradiol (2‐OHE~2~), may play an important role in estrogen