The role of calcium ions in the stabilit
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Eijsink, V. G.H. (author);Matthews, B. W. (author);Vriend, G. (author)
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Article
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2011
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Cold Spring Harbor Laboratory Press
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English
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## Abstract Thermolysin and other secreted broadโspecificity proteases, such as subtilisin or alphaโlytic protease, are produced as preโproโproteins that stay at least partially unfolded while in the cytosol. After secretion, the proโproteases fold to their active conformations in a process that in