๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

The role of calcium in the pharmacology of mania

โœ Scribed by Dr Timothy G. Dinan; Dr Martin Elphick; Dr Trevor Sharp

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
666 KB
Volume
4
Category
Article
ISSN
0885-6222

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โœฆ Synopsis

Episodes of mania in bipolar affective disorder patients are associated with a decrease in cerebrospinal fluid calcium. A reduction in extracellular calcium in most neurones leads to a decrease in calcium-activated potassium conductance mechanisms. Such mechanisms help govern the rate of action potential generation by neurones, and thus the rate of information processing. The dopamine hypothesis of neuroleptic action cannot explain the antimanic actions of lithium, calcium antagonists or carbamazepine. This paper proposes a common mechanism of action for such substances -namely, an action on calcium-activated potassium conductances.

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