The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression
โ Scribed by Dingcheng Gao; Vivek Mittal
- Book ID
- 116758214
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 362 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1471-4914
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## Abstract Radiosensitive host cells capable of potentiating tumor neutralization by immunocytes in normal recipients are present only in the bone marrow and not in the spleen or thymus. This was shown by selectively eliminating either the bone marrow, spleen or thymus of groups of mice and then s
## Background: Interactions between bone marrow-derived cytokines, growth factors, and tumors play a critical role in both the homing of tumors to the bone and the development of bone metastasis. bone is a storehouse of latent growth factors produced by stromal cells and osteoblasts that, when acti