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The role of bisphosphonates in hormone-refractory prostate cancer

✍ Scribed by Fred Saad; Pierre Karakiewicz; Paul Perrotte

Publisher: Springer-Verlag
Year: 2005
Tongue: English
Weight: 232 KB
Volume: 23
Category: Article
ISSN: 0724-4983
DOI: 10.1007/s00345-004-0472-2

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Prostate cancer is considered to be one of the most hormone-dependent human malignancies. As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer. Mutations in the coding region of the AR gene have been found in b