✦ LIBER ✦

The role of antigen-presenting cells in the regulation of allergen-specific T cell responses

✍ Scribed by Martien L Kapsenberg; Catherien MU Hilkens; Eddy A Wierenga; Pawel Kalinski

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 644 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80077-0

No coin nor oath required. For personal study only.

✦ Synopsis

Allergic reactions in atopic patients follow from a generalized enhanced polarization of Th cells, predominantly imposed by factors derived from antigen-presenting cells from a pathogen-stressed tissue; these sample information not only on antigen structures but also on the nature of the stress. Antigen-presenting cells of atopic individuals show aberrant characteristics which, through a highly interactive communication network, play an active role in aberrant Th-cell polarization. This generalized bias may follow from intrinsic abnormalities of antigen-presenting cells and also from a low degree of cross-regulation by micro-organisms.

📜 SIMILAR VOLUMES

Regulation of T-cell responses by CNS an

Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes

✍ Francesca Aloisi; Francesco Ria; Luciano Adorini 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 219 KB

mmune privilege of the CNS is thought to be maintained by the tight endothelial junctions of the blood-brain barrier (BBB), the absence of adequate connections with the immune system, and the presence of an immunosuppressive microenvironment. This strict regulation of CNS immune reactivity is overco

Decrypting the spectrum of antigen-speci

Decrypting the spectrum of antigen-specific T-cell responses: the avidity repertoire of MBP-specific T-cells

✍ B. Mazzanti; B. Hemmer; E. Traggiai; C. Ballerini; H.F. McFarland; L. Massacesi; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB

Myelin basic protein (MBP) is a well-characterized autoantigen potentially involved in the pathogenesis of the most common human demyelinating disease of the central nervous system (CNS), multiple sclerosis (MS). It is known that MBP-specific T-cell responses differ widely among different individual

Regulation of T cell-mediated cytotoxic

Regulation of T cell-mediated cytotoxic allograft responses. I. Evidence for antigen-specific suppressor T cells

✍ H. Wagner; A. Starzinski-Powitz; K. Pfizenmaier; M. Röllinghoff 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 English ⚖ 682 KB

## Abstract Murine lymph node cells draining a local lymphoid cell allograft (LNd) exhibited weak cytolytic activity when tested immediately after surgical removal, However, upon mere __in vitro__ cultivation, high cytotoxic activity developed. The __in vitro__ generation of cytotoxic activity coul

Antigen specific suppression of T-cell r

Antigen specific suppression of T-cell responses — the veto concept

✍ Hans-Georg Rammensee; Michael J. Bevan; Pamela J. Fink 📂 Article 📅 1985 🏛 Elsevier Science 🌐 English ⚖ 352 KB

The role of ICAM-1 in the induction of a

The role of ICAM-1 in the induction of antigen-specific T cell hyporesponsiveness

✍ Stephen W. Chung; Barbara Gould; Reginald Gorczynski 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 609 KB

Activation of specific T cell lines by t

Activation of specific T cell lines by the antigens avidin and myelin basic protein in the absence of antigen-presenting cells

✍ Daniel M. Altmann; Ofer Lider; Daniel C. Douek; Irun R. Cohen 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 566 KB

## Activation of specific T cell lines by the antigens avidin and myelin basic protein in the absence of antigen-presenting cells We have investigated the specific activation by soluble antigen of rat or mouse longterm T helper cell lines using antigen-presenting cell (APC)-free culture conditions