The role of an endothelial cell lining in limiting distal anastomotic intimal hyperplasia of 4-mm-I.D. Dacron grafts in a canine model
✍ Scribed by Graham, Linda M. ;Brothers, Thomas E. ;Vincent, Christopher K. ;Burkel, William E. ;Stanley, James C.
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 637 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
The effect of an endothelial cell (EC) lining on intimal hyperplasia at the distal anastomosis of . Dacron grafts was assessed in a canine model. Enzymatically derived autologous EC were used to seed 14 to 17 cm long, 4 mm I.D., knitted Dacron aortoiliac grafts implanted in an end-to-side manner in six dogs (Group I). Unseeded grafts were similarly implanted in six control dogs (Group 11). All animals received acetylsalicylic acid (325 mg PO qd) 24 h prior to graft placement and for 2 weeks postoperatively. Distal anastomotic intimal hyperplasia (AIH) and luminal surface EC coverage were quantitated at the conclusion of a 16-week study period. Patency for Group I and Group I1 grafts were 90% and 55%, respectively ( p = 0.07). Maximum AIH, defined as the maximum reduction of luminal cross-sectional area at the distal anastomosis, was not significantly different between Group I (13.1 2 8.0%) and Group I1 (15.1 f 7.3%) conduits. However, AIH was inversely related to the extent of luminal EC coverage (r = -0.6, p c 0.05), thus greater endothelialization was associated with decreased AIH. These data support the idea that EC coverage of the luminal surface of prosthetic vascular grafts may limit the development of AIH.