The effect of external ATP on both the membrane potential and the transmembrane current of the thyroid cell line FRTL-5 has been investigated in the patch-clamp whole-cell recording configuration. In the resting situation the membrane potential is around -70 mV and the membrane acts like a K(+)-sens
✦ LIBER ✦
The role of adenosine A1 receptors in the ATP-evoked Ca2+ response in rat thyroid FRTL-5 cells
✍ Scribed by Minna Vainio; Kid Törnquist
- Book ID
- 114012812
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 181 KB
- Volume
- 390
- Category
- Article
- ISSN
- 0014-2999
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The aim of the present study was to investigate the mechanisms regulating endothelin-1 (ET-1) secretion in rat thyroid FRTL-5 cells. ET-1 was found to be secreted after stimulation with adenosine and ATP. The release of ET-1 was sensitive to pertussis toxin, indicating a role of G-proteins in the st