𝔖 Bobbio Scriptorium
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The role of actin polymerization in Amoebal Chemotaxis

✍ Scribed by Peter C. Newell

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
534 KB
Volume
5
Category
Article
ISSN
0265-9247

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✦ Synopsis

A very rapid cellular event that follows chemotactic stimulation of leucocyte and cellular slime mould amoebae is a massive polymerization of G to F actin and its association with the cytoskeleton. In the cellular slime moulds this event occurs within 3-5 sec of cell surface binding of chemoattractants. It is correlated with rapid pseudopodium extension and may be a cell orientation mechanism. Curiously, before an amoebae moves away in the direction of its new pseudopodium it rounds up or 'cringes' for 10-20 sec, an event correlated with a massive actin depolymerization. Transduction of the chemotactic signal involves

Ca2+ release from internal stores by inositol trisphosphate.

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