The role of a transient potassium current in a bursting neuron model

✍ Scribed by Evyatar Av-Ron

• Publisher: Springer
• Year: 1994
• Tongue: English
• Weight: 899 KB
• Volume: 33
• Category: Article
• ISSN: 0303-6812
• DOI: 10.1007/bf00160174

✦ Synopsis

Presented here is a biophysical cell model which can exhibit lowfrequency repetitive activity and bursting behavior. The model is developed from previous models (Av-Ron et al. 1991, 1993) for excitability, oscillations and bursting. A stepwise development of the present model shows the contribution of a transient potassium current (IA) to the overall dynamics. By changing a limited set of model parameters one can describe different firing patterns; oscillations with frequencies ranging from 2-200 Hz and a wide range of bursting behaviors in terms of the durations of bursting and quiescence, peak firing frequency and rate of change of the firing frequency.