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The role of a conserved guanosine residue in the hammerhead-type RNA enzyme

✍ Scribed by Osamu Odai; Hidekazu Hiroaki; Takeshi Sakata; Toshiki Tanaka; Seiichi Uesugi

Book ID
115923173
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
298 KB
Volume
267
Category
Article
ISSN
0014-5793

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πŸ“œ SIMILAR VOLUMES

Synthesis and Enzymic Hydrolysis of Olig
Synthesis and Enzymic Hydrolysis of Oligoribonucleotides Incorporating 3-Deazaguanosine: The Importance of the Nitrogen-3 Atom of Single Conserved Guanosine Residues on the Catalytic Activity of the Hammerhead Ribozyme
✍ Frank Seela; Harald Debelak; Lori Andrews; Leonid Beigelman πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 German βš– 223 KB

## Abstract Four base‐modified hammerhead ribozyme/substrate complexes were constructed in which single guanosine (1) residues were replaced by 3‐deazaguanosine (2) in the positions G~5~, G~8~, G~L2.1~, and G~12~. The base‐modified ribozyme complexes were prepared by solid‐phase synthesis of oligor