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The Ro 15–1788 cue: Evidence for benzodiazepine agonist and inverse agonist properties

✍ Scribed by Jean De Vry; Jef L. Slangen

Book ID
115879203
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
369 KB
Volume
119
Category
Article
ISSN
0014-2999

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Chronic treatment with Ro 15-1788 distin
Chronic treatment with Ro 15-1788 distinguishes between its benzodiazepine antagonist, agonist and inverse agonist properties
✍ Sandra E. File; J. Dingemanse; H. L. Friedman; D. J. Greenblatt 📂 Article 📅 1986 🏛 Springer 🌐 English ⚖ 570 KB

Ro 15-1788 (fiumazepil) is an imidazodiazepine that is able to antagonise most of the behavioural actions of the benzodiazepines, as well as having some intrinsic effects. Acute administration of Ro 15-1788 (10 mg/kg) decreases social interaction between male rats and elevates exploratory head-dipp