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The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals

✍ Scribed by Thomas Meyer; Andrea Fromm; Christoph Münch; Birgit Schwalenstöcker; Anne E Fray; Paul G Ince; Stefan Stamm; Georg Grön; Albert C Ludolph; Pamela J Shaw


Book ID
119470371
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
379 KB
Volume
170
Category
Article
ISSN
0022-510X

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## Abstract In amyotrophic lateral sclerosis (ALS) non‐neuronal cells play key roles in disease etiology and loss of motoneurons via noncell‐autonomous mechanisms. Reactive astrogliosis and dysfunctional transporters for L‐glutamate [excitatory amino acid transporters, (EAATs)] are hallmarks of ALS