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The Ring of the Rhodopsin Chromophore in a Hydrophobic Activation Switch Within the Binding Pocket

โœ Scribed by Paul J.R. Spooner; Jonathan M. Sharples; Scott C. Goodall; Petra H.M. Bovee-Geurts; Michiel A. Verhoeven; Johan Lugtenburg; Arthur M.A. Pistorius; Willem J. DeGrip; Anthony Watts


Book ID
116661598
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
466 KB
Volume
343
Category
Article
ISSN
0022-2836

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## Abstract The change of selectivity and the induction of antagonism by the insertion of 1,2,3,4โ€tetrahydroisoquinolineโ€3โ€carboxylic acid (Tic) in the second position of several opioid peptides have led to the interpretation of Tyrโ€Tic as a specific message domain for __ฮด__โ€opioid antagonists and