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The retinoblastoma tumour suppressor in development and cancer

✍ Scribed by Classon, Marie; Harlow, Ed

Book ID
109949085
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
469 KB
Volume
2
Category
Article
ISSN
1474-1776

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## Abstract The p16^Ink4^/MTSI/CDKN2 is a cell‐cycle regulatory inhibitor of cyclin‐dependent kinase 4 (cdk4), and a candidate tumour suppressor whose gene on chromosome band 9p21 is frequently deleted or mutated in diverse types of cancer. Cdk4 in association with its D‐type cyclin partners, toget