The results of treatment in 100 patients with limited-stage small cell lung cancer

✍ Scribed by Xuyi Liu; Xiaokui Li; Yubin Pang; Qingqi Li; Xueyi Wang; Wenjong Shen

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 472 KB
• Volume: 71
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19930115)71:2<326::aid-cncr2820710210>3.0.co;2-u

✦ Synopsis

Background:

In an attempt to improve treatment results of small cell lung cancer (sclc), combined induction chemotherapy and thoracic and prophylactic brain radiation therapy were administered.

Method:

From december 1980 to december 1987, 112 patients with limited-stage sclc were treated with combination induction chemotherapy and thoracic or prophylactic brain radiation therapy; 100 were evaluable.

Results:

The complete response rate was 40%, and complete and partial responses totaled 94%, with a 5-year survival rate of 23%. there was no difference in remission and survival rates between three-drug and four-drug induction chemotherapeutic regimens. six chemotherapeutic courses produced longer survival than less therapy. although the occurrence of brain metastases was no different with or without prophylactic brain radiation therapy, the 3-year survival after this procedure was improved.

Conclusion:

Treatment of limited-stage sclc with induction chemotherapy and thoracic and prophylactic brain radiation therapy produced improved remission and survival rates.