## Abstract ## BACKGROUND Imatinib mesylate is a selective tyrosine kinase inhibitor of cβabl, bcr/abl, cβkit, and plateletβderived growth factorβreceptor (PDGFβR). cβkit is expressed in most patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) and PDGF has been implicated
β¦ LIBER β¦
The results of imatinib therapy for patients with primary eosinophilic disorders
β Scribed by Grzegorz Helbig; Beata Stella-Holowiecka; Sebastian Grosicki; Grazyna Bober; Magorzata Krawczyk; Jerzy Wojnar; Andreas Reiter; Andreas Hochhaus; Jerzy Holowiecki
- Book ID
- 114794015
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 82 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0902-4441
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Gain-of-function D816V point mutation within the kinase domain of the transmembrane receptor KIT is found in the great majority of patients with systemic mastocytosis (SM) and is attractive therapeutic target. Twenty patients with SM were enrolled during 2003-2005 in phase II clinical trial with ima