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The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue

✍ Scribed by Ester Hidalgo; Sarah J. Essex; Lorraine Yeo; S. John Curnow; Andrew Filer; Mark S. Cooper; Andrew M. Thomas; Helen M. McGettrick; Michael Salmon; Christopher D. Buckley; Karim Raza; Dagmar Scheel-Toellner


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
339 KB
Volume
63
Category
Article
ISSN
0004-3591

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TEA (T early alpha) is a genetic element located upstream of the TCR-J Β§ cluster. Thymocytes from mice carrying a targeted deletion of TEA do not rearrange their TCR Β§ locus on a window spanning the first nine J Β§ segments. This led us to the hypothesis of TEA having a "rearrangement focusing" activ