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The requirement for glutathione S-transferase in the conjugation of activated aflatoxin B1 during aflatoxin hepatocarcinogenesis in the rat

✍ Scribed by G.E. Neal; J.A. Green

Book ID
113136630
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
948 KB
Volume
45
Category
Article
ISSN
0009-2797

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Fisher-344 male rats were fed 1.6 ppm of aflatoxin B 1 (AFB 1 ) continuously and intermittently for several weeks. At various time periods, DNA was isolated from the testes and livers and analyzed for AFB 1 -DNA adducts. The ability of the testis to detoxify AFB 1 was also investigated by the glutat