The replication and transcription activator (RTA) of Kaposi’s sarcoma-associated herpesvirus/human herpesvirus-8
✍ Scribed by Zhilong Yang; Charles Wood
- Publisher
- SP Higher Education Press
- Year
- 2010
- Tongue
- English
- Weight
- 236 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1674-7984
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Recently, a novel DNA virus has been molecularly cloned from Kaposi's sarcoma (KS) tissue, a tumour common in acquired immune deficiency syndrome (AIDS). Analysis of the viral genome confirms that it is a relative of human herpesviruses and the virus has been designated HHV-8. Epidemiological eviden
## Abstract We report the molecular characterization of 38 new Kaposi's sarcoma‐associated herpesvirus (KSHV) strains from Russian patients with either classic (25 cases), epidemic/AIDS‐associated (7 cases), or posttransplant/immunosuppressed patients (6 cases), or Kaposi's sarcoma (KS). While a co
We studied the seroprevalence and transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8), among 215 Ugandan children, adolescents and young adults. We measured antibodies to a latent nuclear antigen (LANA) and a lytic cycle protein encoded by open reading frame (orf) 65. Infection with
The K1 locus is a highly polymorphic locus in the genome of human herpesvirus 8, the causative agent of Kaposi's sarcoma. Analysis of the pattern of nucleotide substitution among alleles at this locus supported the hypothesis that natural selection has acted to enhance amino acid diversity in the tw