The renal excretion of phenol red by the aglomerular fishes, Opsanus tau and Lophius piscatorius
✍ Scribed by Shannon, James A.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1938
- Tongue
- English
- Weight
- 412 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0095-9898
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✦ Synopsis
VCTe have previously presented a quantitative analysis of the data in a study of the tubular excretion of phenol red in the dog. This indicated that at low concentrations of free or filterable dye (0.05 to 0.40 mg. per cent) the rate of tubular excretion (milligrams per minute) is closely proportional to plasma concentration ; at higher concentrations this proportionality is lost and the rate of tubular excretion reaches an apparent maximum at a plasma concentration of approximately 6.0 mg. per cent free dye (Shannon, '35). This same general relationship has since been demonstrated to exist in the chicken (Pitts, '38) and in man (Smith, Goldring and Chasis, '38). The importance of establishing beyond doubt the presence or absence of such a maximal rate in the mechanism of tubular excretion is apparent.5 A priori, one might assume that the mechanism of tubular excretion in the glomerular and aglomerular tubule is the same, and since the process may be observed uncomplicated by glomerular activity in the latter, it appeared desirable to make a systematic study Marshall and Crane ( '24) were the first to attempt a systematic description of a process of tubular excretion (i.e., phenol red in the dog). Although the rate of tubular excretion i n glomerular kidneys was incapable of measurement at that time these workers inferred, from the relationship between plasma concentration and rate of total exeretion, that there was a n upper limit to the rate of tubular transfer.