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The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) – Results of an international collaborative study

✍ Scribed by Wolfram Müller; Lawrence J. Burgart; Ruth Krause-Paulus; Stephen N. Thibodeau; M. Almeida; T. Brocker Edmonston; C. R. Boland; C. Sutter; J. R. Jass; A. Lindblom; J. Lubinski; K. MacDermot; D. S. A. Sanders; H. Morreau; A. Müller; C. Oliani; T. Orntoft; M. Ponz De Leon; C. Rosty; M. Rodriguez-Bigas; J. Rüschoff; A. Ruszkiewicz; J. Sabourin; R. Salovaara; Gabriela Möslein

Book ID: 110324714
Publisher: Springer Netherlands
Year: 2001
Tongue: English
Weight: 253 KB
Volume: 1
Category: Article
ISSN: 1389-9600
DOI: 10.1023/a:1013840907881

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## Abstract Clinical criteria, microsatellite analysis (MSA) and immunohistochemistry (IHC) are important diagnostic tools for identification of hereditary nonpolyposis colorectal cancer (HNPCC) patients who are likely to carry pathogenic germline mutations in mismatch repair genes. Based on MSA an