The relative stability of bleomycin metal complexes to metal exchange

✍ Scribed by Adrian D. Nunn

• Book ID: 104778323
• Publisher: Springer
• Year: 1977
• Tongue: English
• Weight: 383 KB
• Volume: 2
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00448108

✦ Synopsis

The resistance to exchange of the bound metal atom of carrier-free 1~ 1in Neomycin by excess cobalt 2+ has been found to be markedly inferior to that of carrier-free 57Co Neomycin. After 1 h in the presence of excess copper more than 50% of the 1 t ~In has been removed from a bleomycin complex, whereas after 18 h less than 5% of the 57Co is removed from a similar bleomycin complex. The instability of carrier-free ~In bleomycin in the presence of copper is proposed as the first step in the pathway whereby transferrin bound 11XIn is formed when 1 ~ ZIn Neomycin is used as a radiopharmaceutical.