✍ Scribed by Martin H. Jones; William Levason; Charles A. McAuliffe; Stephen G. Murray; Denise M. Johns
No coin nor oath required. For personal study only.
The activity of chelated Cu(II) with four different aspirin-like drugs in various superoxide dismutase assays was examined. Prior to these studies the oxidation state of the involved copper was measured by x-ray photoelectron spectrometry and was found to be +I1 throughout. All copper complexes were able to suppress the xanthine-xanthine oxidase mediated reduction of both cytochrome c and nitroblue tetrazolium as well as the formazan formation by KO;! in a specific manner. The hydroxylation of benzo-[a]-pyrene as well as the demetbylation of 7-ethoxycoumarin using induced hepatic rat microsomes could be successfully inhibited by the employed Cu(II) chelates. Cu(II)-acetylsalicylate was the most active copper complex. Our findings support the proposal that Cu(II) chelates are the active forms of aspirin-like antiinflammatory agents.
📜 SIMILAR VOLUMES
Replacing the 3- and 3''-protons of the ligand 2,6-di(pyrazol-1-yl)pyridine L by mesityl groups changes the electronic ground state of [Cu(L) ] complexes from {d x 2-y 2} to {d z 2} . This is the best example so far for a "homoleptic" Jahn-Teller-compressed six-coordinate Cu complex.