The relationship of “shared epitopes” of major histocompatibility complex molecules to autoimmune disease
✍ Scribed by I. R. Mackay; M. J. Rowley; B. D. Tait
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 137 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract At the surface of the murine T lymphoma cell line RMA‐S, the expression of “empty” class I molecules can be dramatically enhanced by culture at 26°C. These class I molecules are unstable following transfer to 37°C unless they are loaded with exogenously added peptides. Class I heterodim
with other HLA alleles. 4,5,7,8 Furthermore, patients with HLA Susceptibility for type 1 autoimmune hepatitis has DR3 present at an earlier age and enter remission less frebeen associated with the major histocompatibility quently during corticosteroid therapy. 4,6,7 They also relapse alleles DRB1\*0
## Abstract A method for the theoretical prediction of the antigenic determinants and the antigen‐interactive receptor sites of immunological proteins from their primary structure would constitute a useful tool for their study. Such a method developed in this laboratory uses hydrophilicity, accessi