In colorectal cancer an association has been found between lack of epithelial basement membrane (EBM) immunostaining in the tumour centre and more extensive malignant spread. Interestingly, ultrastructural investigations suggest that EBM loss at the tumour periphery may be part of an invasive mechan
โฆ LIBER โฆ
The relationship between tumour volume and the extent of spread in colorectal carcinoma
โ Scribed by K. W. M. Scott; R. H. Grace
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 432 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0179-1958
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Collagenolytic enzymes produced by tumor cells are believed to play a significant role in the destruction of surrounding normal tissue and, in certain experimental animal systems, the ability of tumor cells to degrade type-IV collagen (basement membrane collagen) correlates positively with those cel