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The relationship between plasma concentration of valproic acid and its anticonvulsant and behavioural effects in the rat

✍ Scribed by I.F. Tulloch; D.S. Walter; G.M. Hown; S.J. Howe

Book ID
118954530
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
856 KB
Volume
21
Category
Article
ISSN
0028-3908

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The role of metabolites in valproic acid (VPA)-associated hepatotoxicity was studied in rats. The most steatogenic mono-unsaturated metabolite, 4-en-VPA, caused the greatest changes in indicators of beta-oxidation inhibition (dicarboxylic aciduria, beta-hydroxybutyrate reduction); however, the bioch