The relationship between membrane characteristics, functional reactivity of T-lymphocytes, and the progression rate of B-cell chronic lymphocytic leukemia

Expansions of clonal and oligoclonal T c

Expansions of clonal and oligoclonal T cells in B-cell chronic lymphocytic leukemia are primarily restricted to the CD3+CD8+ T-cell population

✍ Charles L. Goolsby; Miroslaw Kuchnio; William G. Finn; LoAnn Peterson 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 150 KB 👁 2 views

B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of mature-appearing clonal B cells exhibiting coexpression of CD5 and CD23. In addition to the accumulation of neoplastic B cells, numerous T-cell abnormalities also occur in B-CLL patients. In this study, the presence,