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The relationship between debrisoquine oxidation phenotype and the pharmacokinetics of chlorpropamide

✍ Scribed by J. Kallio; R. Huupponen; K. Pyykkö

Book ID
110609299
Publisher
Springer
Year
1990
Tongue
English
Weight
267 KB
Volume
39
Category
Article
ISSN
0031-6970

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Marked interindividual variation has been observed in the pharmacokinetics of the antiarrhythmic agent mexiletine. The fact that its urinary excretion is dependent on urinary pH may account, in part, for such variation. The influence that genetic differences in hepatic metabolism of the debrisoquine