The relationship between c-FLIP expression and human papillomavirus E2 gene disruption in cervical carcinogenesis
β Scribed by Wei Wang; Shixuan Wang; Xingfu Song; Ni Sima; Xinhua Xu; Aiyue Luo; Gang Chen; Dongrei Deng; Qian Xu; Li Meng; Yunping Lu; Ding Ma
- Book ID
- 113961011
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 286 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0090-8258
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## Human-papillomavirus (HPV)-E2 protein is involved in gene-expression regulation and replication of HPV genome. Disruption of the E2 gene during viral integration has been proposed as a mechanism of tumoral progression, since the expression of E6/E7 viral oncogenes is allowed. However, retention
Specific antibodies against the C-terminus of E2, produced by affinity purification of polyclonal antisera, have been used to identify the cellular populations which express the HPV 16 E2 transcription factor, in a series of formalin-fixed, paraffin-embedded cervical tissues. Cases were selected for