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The relation between the status of adaptive system and the number of postoperative complications in patients with gastrointestinal cancer: The effect of phenazepam

✍ Scribed by M. N. Ostroumova; N. N. Simonov; V. K. Kovalev; M. I. Bernstein

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
433 KB
Volume
20
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

The decrease in 11‐hydroxycorticosteroids concentration caused by 0.5 mg of dexamethasone administered at 11 pm was studied in 91 primary patients suffering from gastrointestinal cancer. In dexamethasone‐resistant patients postoperative complications developed in 65% of colon cancer patients and in 42% of stomach cancer patients. In dexamethasone‐sensitive patients the complications were observed in 24% and 12% of patients, correspondingly. The elevation of hypothalamic threshold of sensitivity to the inhibiting effect of glucocorticoids, revealed by the dexamethasone suppression test, was considered to be a result of a combined action of age, the tumor itself, and pronounced emotional stress during the preparation for operation. The derivative of benzodiazepin ‐ phenazepam ‐ when administered before the operation in colon cancer patients improved the results of the dexamethasone suppression test and decreased the number of postoperative complications.

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