✦ LIBER ✦

The rel family of proteins

✍ Scribed by Chris Rushlow; Rahul Warrior

Book ID: 102759729
Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 911 KB
Volume: 14
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950140204

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✦ Synopsis

The re1 family of proteins can be defined as a group of proteins that share sequence homology over a 300 amino acid region termed the re1 domain. The re1 family comprises important regulatory proteins from a wide variety of species and includes the Drosophila morphogen dorsal, the mammalian transcription factor NF-KB, the avian oncogene v-rel, and the cellular protooncogene c-rel. Over the last two years it has become apparent that these proteins function as DNA-binding transcription factors, and that their activity is regulated at the level of subcellular localization.

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