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The Regulation of TGFβ1 Induced Fibronectin EDA Exon Alternative Splicing in Human Renal Proximal Tubule Epithelial Cells

✍ Scribed by Phanish, Mysore Keshavmurthy; Heidebrecht, Felicia; Nabi, Mohammad E.; Shah, Nileshkumar; Niculescu-Duvaz, Ioana; Dockrell, Mark Edward Carl


Book ID
127205330
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
586 KB
Volume
230
Category
Article
ISSN
0021-9541

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Thrombin down-regulates the TGF-β-mediat
✍ Jong-Sup Bae; In-San Kim; Alireza R. Rezaie 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB

## Abstract Human proximal tubule (HK‐2) cells are commonly used as cellular models to understand the mechanism by which inflammatory mediators cause renal injury. It has been observed that thrombin stimulates the expression of TGF‐β, extracellular matrix (ECM) proteins and proinflammatory cytokine