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The regulation of mDia1 by autoinhibition and its release by Rho•GTP

✍ Scribed by Lammers, Michael; Rose, Rolf; Scrima, Andrea; Wittinghofer, Alfred

Book ID
110031267
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
530 KB
Volume
24
Category
Article
ISSN
0261-4189

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## Abstract Mutations in Kir2.1 inwardly rectifying potassium channels are associated with Andersen syndrome, a disease characterized by potentially fatal cardiac arrhythmias. While several Andersen‐associated mutations affect membrane expression, the cytoplasmic signals that regulate Kir2.1 traffi