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The Regulation of Intracellular Orthophosphate Concentration

✍ Scribed by G.J. Kemp; A. Bevington

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
579 KB
Volume
161
Category
Article
ISSN
0022-5193

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✦ Synopsis

Even though the intracellular concentration of orthophosphate (Pi) is an important influence on intracellular metabolism, its regulation is not well understood. In this paper a simple model is used to explain how cellular [Pi] is influenced by the transmembrane electrical potential and sodium distribution and by the kinetic properties of active and passive Pi transport, and how these factors affect the dependence of cellular [Pi] on extracellular [Pi] and its response to small displacements from equilibrium. Parts of the analysis are also applicable to other transported metabolites.

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