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The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia

✍ Scribed by Umeda-Yano, Satomi; Hashimoto, Ryota; Yamamori, Hidenaga; Okada, Takeya; Yasuda, Yuka; Ohi, Kazutaka; Fukumoto, Motoyuki; Ito, Akira; Takeda, Masatoshi


Book ID
122764915
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
349 KB
Volume
146
Category
Article
ISSN
0920-9964

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TGFbeta inducible early gene (TIEG) is a novel Krüppel-like transcriptional repressor that was recently shown to increase the activity of the TGFbeta/Smad signal transduction pathway by relieving negative feedback through repression of the inhibitory Smad7. Interestingly, while Smad7 is required for