The regulation of expression of mouse mammary tumor virus DNA by steroid hormones and growth factors
β Scribed by Andrew C.B. Cato; Jutta Weinmann; Sigrun Mink; Helmut Ponta; David Henderson; Arnoud Sonnenberg
- Book ID
- 116007394
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 582 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-4731
No coin nor oath required. For personal study only.
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## Abstract Mouse mammary tumor virus (MMTV) is a hormonally regulated, oncogenic virus of mice. MMTVβlike virus DNA has previously been detected in human breast cancers, liver disease, and liver cancers. It is hypothesized that local hormonal effects might be of primary importance in determining M
The mouse mammary tumor virus enters mammary epithelial cells via a plasma membrane protein that binds to a viral envelope glycoprotein, gp52. In intact cells, this gp52 receptor can be phosphorylated by activators of protein kinase A and protein kinase C (PKC), but this modification does not occur