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The regulation of DNA methylation pattern in the Pcdh-α gene cluster during development

✍ Scribed by Shunsuke Toyoda; Masahumi Kawaguchi; Tomoko Toyama; Masaki Okano; Masaaki Oda; Takeshi Yagi

Book ID
116777156
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
98 KB
Volume
65
Category
Article
ISSN
0168-0102

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## Abstract __O__^6^‐methylguanine‐DNA methyltransferase (__MGMT__) is a DNA repair gene which is frequently methylated in colorectal cancer (CRC). However, it remains controversial whether methylation of specific CpG sequences within __MGMT__ promoter leads to loss of its protein expression, and i