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The regulation of aging: does autophagy underlie longevity?

✍ Scribed by Tibor Vellai; Krisztina Takács-Vellai; Miklós Sass; Daniel J. Klionsky

Book ID
113926341
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
436 KB
Volume
19
Category
Article
ISSN
0962-8924

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Autophagy is involved in cellular protein and organelle degradation, which is mediated by the lysosomal pathway. Autophagocytosis has a key role in cellular housekeeping by removing damaged organelles. During aging, the efficiency of autophagic degradation declines and intracellular waste products a