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The Reformatsky reaction of bromodifluoromethylacetylene derivatives: Application to the synthesis of fluorinated bioactive compounds

โœ Scribed by Yuji Hanzawa; Kazuhiko Inazawa; Akira Kon; Hironobu Aoki; Yoshiro Kobayashi


Book ID
108382865
Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
223 KB
Volume
28
Category
Article
ISSN
0040-4039

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A regioselective aminomethylation of 2,4-dihydroxybenzoyl compounds at the C(3) position was accomplished through a Mannich reaction of phenolic substrates with formaldehyde and secondary amines in methanol, whereas the reaction with primary amines included a subsequent cyclization step to yield the