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The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

✍ Scribed by Miguel Salinas; Lachlan D. Rash; Anne Baron; Gérard Lambeau; Pierre Escoubas; Michel Lazdunski


Book ID
110113634
Publisher
Cambridge University Press
Year
2006
Tongue
English
Weight
752 KB
Volume
570
Category
Article
ISSN
0022-3751

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## Abstract The ‘functional dyad’, a well‐defined pair of amino acid residues (basic and hydrophobic residues), is a key molecular determinant present in most animal toxins acting on voltage‐gated Kv1 channels. It is increasingly used as a working concept to explain how toxins are able to recognize