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The receptor for urokinase-plasminogen activator

✍ Scribed by Francesco Blasi; M. Patrizia Stoppelli; M. Vittoria Cubellis

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
425 KB
Volume
32
Category
Article
ISSN
0730-2312

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✦ Synopsis

Many human cells and cell lines possess a specific receptor that binds urokinase plasminogen activator (uPA) with an affinity of about lo-'' M. Bound enzyme is not internalized, is slowly dissociated, and retains its enzymatic activity. The amino acid sequence of uPA responsible for receptor binding is located within the first 35 aminoterminal residues, ie, in the growth factor domain. Binding, however, is not competed for by other proteins that contain the growth factor domain (including epidermal growth factor). Cells that produce uPA secrete the pro-uPA form, which subsequently binds to the receptor. A431 cells, in fact, have their receptors completely saturated with pro-uPA. It is proposed that uPA:uPA-receptor interaction plays a direct role in physiological and pathological processes that require cell migration.

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