The Receptor for Advanced Glycation End Products Is Highly Expressed in the Skin and Upregulated by Advanced Glycation End Products and Tumor Necrosis Factor-Alpha
β Scribed by Lohwasser, Christina; Neureiter, Daniel; Weigle, Bernd; Kirchner, Thomas; Schuppan, Detlef
- Book ID
- 110049151
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 369 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0022-202X
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## Abstract ## Objective The receptor for advanced glycation end products (RAGE) binds multiple ligands, including S100 proteins, high mobility group box chromosomal protein 1 (HMGBβ1), and AGEs, all of which are present in articular cartilage. Stimulation of RAGE signaling can lead to MAP kinase
Multiligand receptor for advanced glycation end products (RAGE) is expressed in a wide variety of tissues, including the liver. Interactions with its ligands lead to cellular activation and thus prolonged inflammation and apoptosis. RAGE also exists in a soluble, truncated isoform called soluble RAG