The reactivity of 3-methyl-4-nitro-5-styrylisoxazole with some bis-enolisable ketones

✍ Scribed by Mauro F.A. Adamo; Stefano Chimichi; Francesco De Sio; Donato Donati; Piero Sarti-Fantoni

• Book ID: 104251183
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 74 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00765-7

✦ Synopsis

The expected Michael adducts and spiroisoxazolines are obtained from the reaction between 3-methyl-4-nitro-5styrylisoxazole and bis-enolisable ketones. Contrary to reported data, Michael adducts are obtained in good yields only when a substoichiometric amount of base is used, whereas spiroisoxazolines were obtained as the major product when the base is present in a large excess.