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The Reaction of Sodium with Ethyl Trifluoroacetate

✍ Scribed by McBee, E. T.; Pierce, O. R.; Kilbourne, H. W.; Barone, J. A.


Book ID
125969050
Publisher
American Chemical Society
Year
1953
Tongue
English
Weight
318 KB
Volume
75
Category
Article
ISSN
0002-7863

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Reaction of tryptophan with trifluoroace
✍ Jan Bergman; GΓΆran Lidgren πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 226 KB

Trifluoroacetic anhydride {TFAA) in ether quickly (= 5-10 min) converted tryptophau to the crystalline 2-trifluoromethyl-5(4@-oxazolone (2) without racemization. Dissolution of optically active 2 in acetonitrile gave racemic 2, whereas treatment with hot aqueous dioxane gave the isomeric oxazolone (