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The reaction of o-amino aryl carboxylic acids with Grignard reagents. The unusual effect of the N-protecting group on aryl ketone formation

✍ Scribed by Puwen Zhang; Eugene A Terefenko; Joseph Slavin

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
54 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The addition of Grignard reagents to the o-amino aryl carboxylic acids without any additive forms the tertiary carbinol as a major product. Unexpectedly, the aryl ketones are formed as the only isolated product if o-amino moiety of anthranilic acids is protected with Boc, trifluoroacetyl, and pivaloyl protecting groups.

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