The Reaction of N -Isocyaniminotriphenylphosphorane With Biacetyl in the Presence of (E) -Cinnamic Acids: Synthesis of Fully Substituted 1,3,4-Oxadiazole Derivatives via Intramolecular AZA -Wittig Reactions of in Situ Generated Iminophosphoranes
✍ Scribed by Ramazani, Ali; Abdian, Behnaz; Nasrabadi, Fatemeh Zeinali; Rouhani, Morteza
- Book ID
- 125527677
- Publisher
- Taylor and Francis Group
- Year
- 2013
- Tongue
- English
- Weight
- 201 KB
- Volume
- 188
- Category
- Article
- ISSN
- 1042-6507
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## Abstract The reaction of (E)‐3‐aryl‐2‐propenoic acid derivatives with (N‐isocyanimino) triphenylphosphorane proceeds smoothly at room temperature to afford the corresponding 2‐[(E)‐2‐aryl‐1‐ethenyl]‐1,3,4‐oxadiazole via an intramolecular aza‐Wittig reaction in good yields under neutral condition
Reactions of biacetyl (¼ butane-2,3-dione) with (N-isocyanimino)triphenylphosphorane in the presence of aromatic carboxylic acids proceed smoothly at room temperature and under neutral conditions to afford 3-(5-aryl-1,3,4-oxadiazol-2-yl)-3-hydroxybutan-2-one derivatives in high yields. Introduction
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