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The reaction of dimethyltitanocene with N-substituted-β-lactams

✍ Scribed by Isamir Martı́nez; Amy R Howell

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
144 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

2-Methyleneazetidines have been synthesized and isolated by the reaction of b-lactams with dimethyltitanocene, followed by chromatography on deactivated silica. Ecient conversion required that the lactam nitrogen be strongly deactivated. Methyl transfer predominated in reactions with phenyl and benzyl on the lactam nitrogen.

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